Chapter 409 The miserable Aspen Company(1/2)
Among a group of people with yellow hair and white skin at Stockholm Airport, there are two Chinese people who are particularly obvious.
The white people passing by looked at them a few times and listened to them speaking English. Although their clothes were not extravagant, they were neat and elegant. They thought they were from the Bangzi country or the Japanese.
After all, it was still rare to see Chinese people at this time. Even if you did see them, you could easily identify them just by their Mao suit and serious facial expressions.
Lan Lijuan asked her husband about some facilities at the airport and the national conditions of Sweden in her not very fluent English.
Chen Qi held his wife's hand tightly and answered his wife's questions in English as he walked to get his luggage.
From the beginning of the transfer in Hong Kong, Chen Qi required Lan Lijuan to communicate in English throughout the entire process, whether it was between the two of them, going to a convenience store to buy something, or colluding with the flight attendant.
After graduating from technical secondary school, Lan Lijuan studied English every day with the encouragement of her boyfriend Chen Qi at the time.
Later, Chen Qi also took advantage of the opportunity of going abroad to buy a lot of English-language videotapes, including movies and TV series, just to let his wife practice her spoken English.
Of course, the video is a serious video, and there is no shouting: "my god" or "e on baby" throughout it.
Over the past few years, Lan Lijuan has been able to fully read English journals and materials, but speaking has always been her weakness. After all, it is still difficult to learn spoken English without being in an English environment.
Just by watching the video, I can completely understand it, but it is still difficult to speak.
Taking advantage of this opportunity to go to Sweden, Chen Qi was determined to quickly catch up with his wife's spoken English.
No matter what era, those who say that English education is not important, or even push the country to abolish English as the main course in primary and secondary schools, are either stupid or bad.
Chen Qi is now a popular hot chick of ICPF and enjoys VIP airport pick-up treatment.
When the couple came to the exit, the organizer of the ICPF annual meeting was already waiting. After shaking hands, the two parties got into the car and drove quickly towards the hotel.
Yes, Chen Qi came to Sweden this time mainly to attend the ICPF annual meeting, and he came early and did not come out with the Chinese delegation.
Because when he came to Sweden this time, in addition to attending the annual meeting, he also had a private schedule, which was also the reason why he took Lan Lijuan abroad with him.
That is for his wife's career, he needs to negotiate a cooperation with the Swedish pharmaceutical company Aslila.
At this time, at the headquarters of Aslila, Chairman Denilson was looking at the latest drugs produced by the company with a frown in front of him.
This is a stomach medicine. In order to develop this medicine, the company has been researching it for 15 years from 1970 to 1986.
The investment has accumulated up to 500 million US dollars.
Asrila, among the many pharmaceutical companies in Europe and the United States, can only be regarded as second-rate at best. The company's finances are not very generous, and this US$500 million will kill the company.
Regarding medical research and development, there is a "Rule of 10", which is to spend 10 years and invest 1 billion US dollars, with a 10% success rate.
Therefore, R&D funds account for the bulk of pharmaceutical companies, and they also eat up most of the profits. As a result, out of the 10 topics studied, only one was successful in the end.
If this drug is successful, it may be in a monopoly position. If your drug is unique in the world, you will make a fortune.
If all 10 research projects fail, I'm sorry, but the company will have to bear the loss itself.
But Aslila did not have such good luck.
Because what he developed was a gastric medicine, and throughout the 1970s and 1980s, there were two medicines that dominated the gastric disease market in the world, one was cimetidine and the other was ranitidine.
These two mainstream drugs compete fiercely with each other.
The problem is that when the boss and the second boss compete, the third and fourth boss often die first.
Therefore, Denilson is very worried. How can the drug that his company has finally produced compete with cimetidine and ranitidine?
You must know that cimetidine is produced by SmithKline and ranitidine is produced by Glaxo, both of which are pharmaceutical giants in England.
Neither the company size nor product marketing can be compared to the second-rate company Aslila.
What's even more terrible is that the newly invented drug by Aslila is the same type of gastric acid-inhibiting drug as cimetidine and ranitidine. It has the same effect and efficacy, which makes it difficult to compete.
Although the laboratory report obtained by Denilson confirms that the newly invented drug is far stronger than ranitidine or cimetidine in terms of acid suppression.
But so what?
How to get patients to accept a new drug so that they are willing to pay for it involves how to promote it, which requires a large amount of advertising fees and the purchase of a large number of top international gastroenterologists' websites.
This is another huge expense, and Denilson does not have the courage to compete with the two major pharmaceutical giants.
Moreover, AstraZeneca's new drugs have another disadvantage, that is, their research and development costs are too high, which means they must increase the price of the drug. The current price is 10 times that of ranitidine.
Even if your efficacy is better than ranitidine, your price is 10 times that of ranitidine. Except for the rich, ordinary people will definitely choose cheaper drugs.
Why is the cost of Asrila's new drug so high? It can only be said that this is a product that has had many disasters.
In 1970, AstraZeneca launched a gastrointestinal research project with the intention of inhibiting gastric acid secretion through anesthetic-like compounds. This research was based on lidocaine and synthesized a variety of related compounds.
The synthetic compound did have a good effect on inhibiting gastric acid in rats, but later it was discovered that compound H81/75 was ineffective in humans, so the research was almost stranded.
In 1972, the project of inhibiting gastric acid was restarted with a new method, and a compound CMN131 was developed to inhibit gastric acid secretion. It was found that this compound had acute toxicity.
Yes, the project can only continue to be studied.
In 1973, Aslila discovered the safer benzimidazole H124/26, but unfortunately the compound was already covered by patents of other companies, so it was wasted effort and research and development continued.
After finally developing the metabolite H83/69, we found that it has long-term chronic toxicity that causes goiter and thymus atrophy.
Finally, it was imperative to structurally modify H83/69 again, and thus compound H149/94 was obtained.
This time it is considered a successful research and development, which shows how difficult the process is. Any problem in any step may lead to the failure of the entire project.
The application for a new drug was submitted in 1980, entered the substantive experimental stage in 1982, and the product was finalized in 1986.
A full 15 years of research and development cost a total of 500 million U.S. dollars. Remember, this was 500 million U.S. dollars in the 1970s and 1980s. This would end the life of Aslila.
Denilson, chairman of Asrila, sat in the main seat and listened to the reports of his subordinates.
"We decided to go to the World Pharmaceutical Exhibition in China and do our best to promote it at the conference. The plan is as follows..."
"We have reached a cooperative relationship with Professor Segel from Karolinska University Hospital. He will help us promote the latest drugs at this year's International Society of Gastroenterology..."
"We also plan to invest US$20 million in Europe first and advertising in major countries..."
The reports from his subordinates were more positive than the others, but Denilson had a headache because none of the suggestions were innovative.
What he needs is a blockbuster, explosive publicity, and a unique angle so that people can quickly remember and understand this drug.
However, the promotion plans provided by my subordinates are like boiling a frog in wet water. Not only are they not innovative, they are also very formulaic.
For example, the sponsors behind the "International Society of Gastroenterology" are either Glaxo or SmithKline. Only these two giants in the field of gastroenterology can spend a lot of money.
"International College of Gastroenterology" (WCOG) is the world's mainstream medical association with more than 50,000 members worldwide. Thousands of people gather at each annual meeting.
No matter in terms of scale or influence, it is not comparable to small associations such as ICPF or FSSH.
The two major pharmaceutical giants have spent a lot of money to sponsor this conference, and they will definitely give preferential treatment to these two companies to promote their gastric medicines. How did AstraZeneca get its turn?
Similarly, the products of these two companies have long been widely used in clinical practice, and they have established good cooperative relationships with some of the most famous gastroenterology experts and doctors in the world.
This kind of relationship involves exporting a lot of benefits and requires a lot of dollars, which is equivalent to an "alliance relationship."
This is an extremely strong network, and pharmaceutical companies and well-known doctors are all communities of interest.
Now that Aslila wants to step in, it is equivalent to a third party stepping in. The possibility of success is relatively small, because the wealthy people give money easily and give more.
Fighting for financial resources? Aslila is the younger brother.
Just when Aslila was worrying about the promotion of new products, Chen Qi and Lan Lijuan had already arrived at the hotel.
ICPF President Professor Dewey, Vice President, Professor Johnson from England, and Professor Hashimoto Ken from Japan are all waiting.
The three presidents waited for a while for the subordinate directors. This is something that would never happen in other societies. When a person reaches a certain level, he must pay attention to his character.
But there is no other way. Chen Qi is really amazing. From the first three new surgeries for cleft lip and palate that stunned the venue, to the previous "tubular rhinoplasty", they were all groundbreaking surgeries.
He is so powerful, he is humble, and he is willing to separate his achievements from others. Such a good person without ambition is worthy of the various presidents of ICPF to win over and establish good personal relationships.
Especially Professor Hashimoto Ken, when he saw Chen Qi coming in, he went up and gave him a hug:
"Chen Sang, you are late. We have been waiting for you for a long time. Haha, Doctor Lan, we meet again."
Lan Lijuan also quickly smiled and nodded in greeting: "Professor Hashimoto, I didn't expect to meet again so soon."
Ken Hashimoto stayed in the Yuezhong Fourth Hospital for two weeks for tubular nose surgery. In order to establish friendship with Chen Qi, he often went to Chen Qi's house to have dinner, so he became quite familiar with Lan Lijuan.
Dewey had been to China twice before and was no stranger to Chen Qi’s wife, so he took the initiative to say hello:
"Chen, your beautiful wife is probably afraid of you messing around outside, so she came to supervise you personally. It's over. I don't dare to ask you to go to the bar tonight."
Chen Qi blinked: "It's okay, I can sneak out while my wife is asleep."
Hahaha~~~~
After some joking, the atmosphere became harmonious, and Dewey pulled Chen Qi next to a tall white man:
"Chen, this is Professor Segel from Karolinska University Hospital in Sweden, and he is also the most famous gastroenterologist in Sweden. He has a very good relationship with Aslila Pharmaceutical Company, and I also entrusted me to
A colleague from Ao Clinic helped introduce me."
Human relations are so clever.
You don’t know anyone, but you can go around a few times and you’ll always find the person you need. This is the benefit of having connections.
Chen Qi thought to himself, the world's number one Mayo doctor is really powerful, so he just helped introduce a "middleman", and he found the top doctor in his country.
"Hello, Professor Segel, I am very honored to meet you. Let me introduce you. This is my wife, who is also a physician in our country. She once published an article "Unknown findings in the gastric mucosa" in the Lancet magazine in 1983.
Bacillus" thesis."
To be continued...