Chapter two hundred and seventieth
As the visit continued, Yuwen Wen came to a yard surrounded by deep grooves and high walls. After passing the suspension bridge, he found that there were several tabby cats lying on the corner and on the wall basking in the sun.
The kittens responded to the visitors and continued to take a nap.
Yu Wenwen walked into the room and placed a large number of iron cages on the wooden racks in the room, and there were mice in each cage.
There are hundreds of mice in this house. Yuwen Wen looked at these mice and thought about Yuchi Chifan's performance in this place.
Just like many women, Yuchi Chifan was born afraid of mice and was so scared that he could not even walk the road if he really saw so many mice here.
Not only that, I will also tremble all over, and I can't stand steadily, with a look of crying without tears.
Yu Wenwen put away his thoughts and began to listen to Lu Wenhua talking about the cultivation plan of experimental mice.
There are so many mice in this place, of course, for experiments. According to Lu Wenhua's introduction, the technical solutions for penicillin development need to be adjusted greatly, and several independent technical routes are started at the same time, which requires a large amount of experimental consumables, including experimental mice.
There are many types of mice. The mice used for experiments do not need to be too big, so the experimental mice grown today are all mice.
No matter what kind of rat it is, it has strong reproductive ability. A pair of rats can give birth to many offspring in a year, and then the offspring will quickly mature and continue to reproduce.
The experimental mice reproduce very quickly and can meet the needs of drug experiments. Compared with raising cats and dogs to do experiments, it is more efficient and cheap.
Previously, the development and efficacy experiments of penicillin were focused on "clinical", that is, the skin tests were performed on the sick patients, and then the penicillin products were injected to observe whether the efficacy was effective.
This approach cannot be wrong, but Lu Wenhua and his colleagues have recently summarized the experience and learned, believing that when the ingredients of penicillin products are extremely unstable, there are too many uncertain factors for using patients to conduct experiments, so it is difficult to determine where the problem of the failure of the experiment is.
Patients with lung disease may have different responses to the same penicillin product due to different personal constitutions, different severity, and even different health conditions. This is "individual difference".
In this case, the efficacy experiment is strictly not very comparable.
Experimental mice also played a role in the development of penicillin in the past, but people still tend to conduct large-scale human experiments and constantly try to "stricken fortunes". This actually means taking shortcuts.
Now it seems that we still have to go step by step honestly and cannot be impatient.
In the new technical solution, the efficacy experiment of penicillin products must pass the experimental rats. If even the diseased experimental rats cannot be cured, there is no need to waste time doing "clinical trials".
The experimental mice reproduce very quickly and can conduct large batches of drug efficacy experiments on various penicillin products. However, it will be much trouble to find patients who are sick and willing to take the drug test.
Yuwen Wen agrees with this idea.
Using rats as the subject of drug experiments is not an idea that people of this era can come up with. Although Yuwen Wen is not a medical student, he knows the term "experimental mouse", so the cultivation of experimental rats began in Xiyang, Huangzhou.
However, white-haired rats were not found in Huangzhou, so over the past decade, all the experimental mice cultivated in the laboratory were of normal hair color (gray, brown).
Of course, Yuwen Wen didn't know how to cultivate excellent experimental mice. The experimenters inbreed the experimental mice according to the method of raising horses, and at the same time recorded the mouse lines.
Record the bloodline for each rat and make a "genealogy" for each rat family.
Such reproduction lasted for more than ten years. The offspring had deformed, weak, irritable personality, poor appetite, slow reaction or excessive rat lines were eliminated. The laboratory specializing in cultivating experimental mice continued to breed inbreeding from various rat families, and finally screened out qualified experimental mouse lines.
Based on this mouse system, laboratories in various places began to cultivate experimental mice, and then widely used for toxicity testing of various chemical reactants. Taking Wuzhuangguan in Xiyang, Huangzhou as an example, there are hundreds of experimental mice consumed every month.
The laboratory in Chang'an also "introduced" the breeding of experimental mice, but the breeding scale was not large. Not long ago, strange things appeared among the experimental mice cultivated by the laboratory in Chang'an.
A "rat couple" with normal hair color actually gave birth to a litter of white "rat children".
Now, Yu Wenwen was in front of a incubator, looking at the nest of "weird" in the box, and was filled with emotion.
It turns out that the ancestor of the experimental white mice was an albino mutant rat... No wonder I searched for more than ten years but couldn't find the white-haired rat...
Yuwen Wen thought, looking at these little white mice, the more he looked at them, the more he felt like he was. He felt that compared to those ordinary gray mice, the white mice in front of him could really be called "rat beauty".
At this time, the classics should be cited to describe the "appearance" of a rat beauty. Yuwen Wen thought about it and thought of that passage.
Weird and elegant, beautiful and elegant.
Such a white mouse deserves the title of "Shuzhi Fengguang". Yu Wenwen was very satisfied with the cultivation results and asked: "Previously, did you say that the consumption of experimental mice will increase greatly?"
Lu Wenhua replied: "Your Majesty, this is true. It is expected that more than 2,000 rats will be used every month. Weicians and others will use exhaustive methods to find the most suitable purification technology to obtain penicillin extracts with stable efficacy."
"Well, you apply for a report immediately. I'm sure these white rats must breed, the more the better!"
......
"There is a girl alone, and she is in bed, and she is beautiful and elegant, and she is so beautiful..."
Yuwen Wen hummed the clip from Sima Xiangru's "Beauty Fu", lay on the couch with his legs crossed, feeling the coolness of the "air conditioner", which was very comfortable.
As the emperor, he acted like this, of course because he was in the bedroom and there were no idle people in the way. He looked at the clock and felt better as time approached.
Not long ago, Yuchi Chifan returned from Yecheng. As the saying goes, a small separation is better than a newlywed. Although he is an old husband and wife, Yuwen Wen still fulfilled his husband's responsibilities well and paid the "public grain".
But he felt that it was not enough because there was still a "late payment fee" that he had not paid.
Although more than 20 years have passed, for Yuwen Wen, his Sanniang is still the best.
Yuchi Chifan's voice, appearance, smile and appearance are his first memory after coming to this era. He has been remembered in his heart and will never forget it. No one can replace Yuchi Chifan's position in his mind.
Even in the future, everyone will grow old and wrinkle on their faces, becoming little old men and old ladies, he will accompany Yuchi Chifan and walk through the last part of his life together.
Yuwen Wen turned around and looked at the clock again, looking forward to it: Which script should I choose tonight’s ‘sitting drama’?
After a while, Yuchi Chifan arrived as scheduled. Although he was wearing casual clothes and did not dress up in particular, Yuwen Wen was still in a state of interest: he had to change his clothes in a while, so it didn't matter.
But when Yuchi Chifan came in, Yuwen Wen always felt something was wrong and he couldn't say what was wrong.
Yuchi Chifan sat beside him, Yuwen Wen sniffed gently, and smiled and said, "Sanniang has another fragrance today... Hum? No."
No, the extra fragrance does not come from Yuchi Chifan.
He glanced at the palace maid standing beside him, feeling a little disgusted, and looked at the beauty again: "Si Niang, you are naughty again."
Yuchi Chifan laughed and said, "Your Majesty, why are you confused?"
"Isn't it Si Niang?" Yuwen Wen was stunned for a moment, then savored the name Yuchi Chifan called him "Your Majesty". Realizing that there was an outsider, he waved his hand to the palace maid without looking back: "You go back."
The palace maid was stunned when she heard this and looked at Yuchi Chifan. Seeing that Yuwen Wen's eyes had not moved away from his face, Yuchi Chifan was a little hesitant, and then said softly: "Your Majesty..."
"Well, what's the matter?" Yuwen Wen still looked at Yuchi Chifan.
"I am inconvenient, so I cannot serve Your Majesty at any time..."
"It's okay, Si Niang is there."
"Uh..." Yuchi Chifan looked at Yuwen Wen and said, "I'm selected a beauty, tonight... Is it good to let the beauty serve His Majesty?"
"Hmm? Beautiful...what is beautiful?" Yuwen Wen couldn't turn his mind. When he saw Yuchi Chifan calling the palace maid closer, he turned to look.
After a closer look, I couldn't help but be stunned.
Very...so beautiful!
Just now, the palace maid came in with the queen, and Yuwen Wen's attention was all on Yuchi Chifan, so the woman did not attract his attention at all.
Now, he noticed.
A graceful beauty with a graceful figure, wearing a well-fitting dress, stood in front of him, exuding a faint fragrance on her body, like a lotus that emerged from the water.
He has delicate facial features, melon-shaped face, willow-leaf eyebrows, Yin Tao's small mouth, and his cheeks are flushed, which looks like a sinking fish and falling geese.
A pair of big watery eyes and a charming look made Yu Wenwen, who had a high vision, look at it, and his instant evaluation was "So beautiful!"
Seeing Yuwen Wen staring at the woman, Yuchi Chifan continued, "This beauty is a concubine..."
The voice of her speech came to an abrupt end because she felt the changes in Yuwen Wen and was so scared that she couldn't even speak.
When the husband's emotions fluctuate greatly, his ears will involuntarily move, and she is very clear about this.
Now, my husband's ears are moving.
Yuwen Wen turned his head and looked at Yuchi Chifan. His eyes seemed to be filled with fire. An evil fire in his chest rushed upwards, and a storm arose in his heart:
What...what does it mean? What do you do to make a woman who is inexplicable?
Chapter completed!