The 127th chapter important news (2)
Everyone immediately became excited. Although 25 times the price-to-earnings ratio and 2.5 times the price-to-book ratio are not cheap for United Group, at least they are below the market average. What is more important is that bond qualifications are retained from July 1929, and will be opened at the annual repayment of principal and interest within five years. This situation where you can attack and retreat and defend, coupled with the joint guarantee of United Group's mortgage of other listed shares, make reporters believe that it is to take care of the interests of investors to the greatest extent.
Of course, United Group itself also makes a lot of profits: reducing the current general financing cost of about 4.5% to 1.5%, which will reduce the financing interest of three points per year, and save US$100 million in financing costs a year.
"Third, it is the first innovative and epoch-making antibacterial drug of United Medicine that has passed the clinical verification of hospitals and the evaluation and recognition of FDA. It will be fully launched across the United States, which will help save the lives of thousands of patients. The name of this drug is sulfonamide. Now, please invite the inventor of this drug, Mr. Gerhard Domak, to describe the principle of its function and its value to you."
Although "drugs" were rampant in the late 19th century, real doctors knew that only quinine, aspirin, and morphine had some effect, and the others could only wait for the patient to heal themselves. In this case, everyone was frantically looking for drugs that could fight bacteria. Paul Erlich was the first to achieve limited success and found 606 (arsenic Vannemin) to effectively treat syphilis, thus creating the era of chemotherapy. However, 606 had great side effects and could only treat syphilis. Therefore, chemists continued to rush in, one of the lucky ones called Domak.
As a medical student, he was injured in the First World War and then became a "medical soldier". He witnessed countless wound infections, especially gas gangrene. The doctor had no choice but to be honest. Perhaps because of the doctor's powerlessness, Thomak made ambitions to conduct scientific research and vowed to find drugs to treat bacteria. But the fledgling "scientific research dog" was poor enough, so poor that he didn't have the courage to propose to his girlfriend who had been in love for nine years until he died of the second disaster.
After marriage, he worked and lived both ways. While finding a job in a university pathology department, he insisted on studying bacteria, immunity and pathology, and gave birth to three children. However, his life was as difficult as ever, but good luck began to favor him. The president came to him. At that time, Contini searched for unsuccessful talents in German universities and offered a higher salary than Germany. He went to work in Italy with the crowd. Domak also arrived in Italy.
Originally, his ambition was to find a job in the medical department to support his family. If he had the conditions, he would do scientific research. So he wrote this clearly in his job search intentions. Later, he obtained a teaching position and was assigned to work in the Roman Medical College. But it was just like this. This was also the school where Ada was studying. Contini met Thomas when he was looking for Ada. He recognized Contini like countless speculators, and then rushed over to introduce his research ideas like a moth to the flame, hoping that 99% of adventurers who were recognized would be driven away by the bodyguards, because Contini knew whether their "invention" was reliable. But Thomas was 1% lucky. He told his ideals and described the fact that he had surgery on streptococci. Anyway, the president was waiting for his girlfriend to get off get out of class, and he was idle.
Streptococcus infections are common and fatal in this era. Once conquered, there will be a broad market prospect. However, there are many types of streptococci, and there are differences in pathogenicity among species. It is impossible to try each streptococci? On this issue, Domak made a decisive choice: No matter how many streptococci there are, I want the most virulent one! He collected samples from patients who died of streptococci infection, cultured and isolated to infect mice, hoping to find strains with 100% infection and lethality rates, which can be called "the most virulent". After several months of hard work, before he talked to Contini, he had found strains that could still cause all inoculated mice to die within two or three days after diluting the culture medium to a hundred thousand times. So far, the animal model of streptococci infection was successfully established.
Contini's first impression was that he could use bacterial weapons, but then he felt that it was wrong. This trick was too troublesome and the cost was too high. He should look for drug treatment in the opposite direction, so he blurted out: "You can try penicillin. Even if there is no penicillin, it is okay to use sulfonamide. It is said that this thing can deal with streptococci..."
It was Domak's turn now and was stunned: "What is penicillin? What is sulfonamide?"
Contini then remembered that the "penicillin" in this era had not been found, and the "sulfonamide" had not been invented at all. He knew that it was Fleming, but he couldn't figure out how the sulfonamide came about, and finally he stammered and said that there were many people like Thomak, all kinds of like liars, and he was not sure whether it would succeed.
But a few days later, Thomak came excitedly and said that he had found the patent for sulfonamide. This thing had applied for a patent 18 years ago, but it had no effect at all. He lay there quietly and became moldy. He came to ask the president how to know and how to do it. Thomak dared not test it rashly. He thought that sulfonamide was just an intermediate product or raw material, and there must be industrial procedures.
At this time, Contini could fully recall the entire incident: in history, wasn’t it that Domak connected azo dye and sulfonamide together, and thus gave birth to the first antibacterial drug, prontosil! So he immediately instructed Domak to suspend classes for the test, and hinted that he could boldly find a patient to try it out. He was responsible for the bottom line, wasn’t he just to pay some money if he died!
With the president's promise and good test conditions, Doumak is of course bold to get started. This time, the sulfonamide does not need chemical dyes, and Doumak's daughter does not need to take on the test. He directly got the secret recipe for conquering streptococci from the sulfonamide.
What's more coincidental is that the sulfonamide patent will expire soon. Since it has been in a state of no interest, the original patent owner transferred it to the United Laboratory at an extremely cheap price. Under the United Group's activities, the German Patent Office agreed to extend the patent protection period by another 5 years on the grounds of the new application of the original patent, forming a 20+5 pattern. That is, by 1933, the United Group can guarantee the exclusiveness of the sulfonamide patent, which laid the foundation for the establishment of United Medicine. In Contini's view, these 5 years are crucial, and more than 5 years is enough for United Group to explore the subsequent sulfonamide drugs while waiting for the maturation of penicillin.
In order to respect history, Contini still set the product name of the sulfonamide drug as Bailangduoxi! After passing the US FDA registration, it means that all the European and American powers have been fully opened. Of course, Bailangduoxi has nothing to do with Germany Bayer now.
"This drug is priced at $9.99 per box and can be widely used for infections caused by streptococcal and has special effects. It will be sold publicly from tomorrow. To express our respect to the American people, we have prepared 1,000 charitable places to prepare information for patients with poor families. It is completely free of charge!"
Everyone began to applaud warmly.
In fact, the production cost of joint medicine is very low, and each box costs less than $1 (including the cost of R&D, registration, promotion, and testing). The first batch of drugs was shipped from Italy by cruise ship after mass production a few days ago. In order to cause a sensation, Domak felt a little high about this pricing, but Contini convinced him: "Your project is successful, but how many projects are being studied in the joint laboratory? Every year I have to invest a lot of funds and hire a large number of people. The success rate is only 2-3%. These funds can only be supported by successful projects, so it is understandable to set the price a little higher. Furthermore, the patent period of this product is only 5 years, and once the patent period is over, although we can continue to sell it, I can guarantee that there will be a large number of imitations. At that time, I can only make a normal profit. You have to consider your business demands."
Thomak was immediately convinced that the entire scientific research team of this drug had done a lot of work. Before it could be seen, the president provided people with good conditions. Now he had just discovered it and had not seen the market effect. The president had delivered all the large residential buildings and cars of United Real Estate. From the other party's standpoint, he really had to fully consider it.
Now the scientific research team is waiting for the option to be cashed. Contini said that United Pharmaceuticals considers ipo from March to April 1929. If successful, team members may become millionaires. When they think of their poor and destitute back then, they didn't even dare to marry. Thomas couldn't help but feel that they had ended their hardships. Now he is thinking about Contini's other words, what is penicillin? Also, who said this to the president. This is either a crazy experiment, a desperate madman, but Domas, but knows that many scientific research experts dare to test everything in order to develop drugs. They ignore everything, and they are completely crazy. Or this is a genius who is unparalleled. Similar to Tesla, he really wants to know it!
Contini, who had an abnormal headache, took countless talks to make the other party believe that this was what an inventor said when he was chatting with him. He saw so many people every day and could not remember who the other party was. However, Dumak did believe it, because there were too many people looking for Contini, and if he hadn't been particularly lucky that day, he would have been forked out by the bodyguards. In fact, the Joint Laboratory has a special process for this kind of inventive letter, and the information summarized will be read by Contini and the General Office of the President. Many projects can eventually become joint laboratories' research projects. Similar to PVC, Bailang Duoxi is a necessary result under scientific guidance.
Contini finally concluded: "The success of Bailangduoxi will promote the listing of United Pharmaceuticals. I look forward to sharing the growth of corporate and the joy of national development like millions of American investors! If the United States is good, Italy is good, and if Italy is good, United Group is good, and vice versa! Long live the great friendship between U.S. and Italy!"
Chapter completed!