The patient of Ou Ye crawled on the ground in a reptile-like position and shouted: "I like to sleep with female students. I have slept with more than 60 female students, hahahaha! So what if I sleep, what can you do to me? Those female students can't even write papers, but it doesn't matter. As long as I sleep with me, I will let them graduate. Ahhaha, so what if I sleep, what can you do to me?"

Professor Qu shouted: "He Yuankai, enough!"

The patient suddenly hugged Professor Qu's thigh and burst into tears: "Professor Qu, I am a patient. You have to explain the situation to them. I am a seriously ill patient. They cannot take me away! I want to stay in the hospital, I want to treat the disease!"

Professor Qu waved his hand: "Take him away!"

The crazy patient was taken away, Shen Qi couldn't help but become alert, while Ou Ye had a disgusted expression on his face.

"Old Qu, what is the situation of He Yuankai? I remember that he seems to be a subject in the clinical trial of triazaoctenol, right? There is something wrong with his mental illness? It shouldn't be a side effect of the drug, right?" Shen Qi was a little nervous. Triazaoctenol finally advanced to the phase i clinical stage. If there are mental side effects, it will be done!

"He is pretending to be crazy and stupid," Professor Qu shook his head and said, "This person is a teacher in the university. I just received the news that he was investigated for embezzlement and misappropriation of project funds."

Shen Qi sighed and was filled with righteous indignation: "Damn! How did such a morally corrupt person recruit him into the test group?"

Lao Qu looked up at the gorgeous sunset in the sky at a 45-degree angle and said deeply: "In the eyes of doctors, there are only patients and non-patients."

Ou Ye was indignant: "This man surnamed He is such a scum! He was investigated for embezzling public funds. He slept with so many female students. Isn't anyone taking care of him?"

Shen Qi said: "Students cannot write papers or fail the exam, so they go to the teacher to ask for mercy and let go. This kind of thing is not uncommon in some universities. A few years ago, I published a mathematical analysis paper. 80% of the students in the Mathematical School failed the exam, and some students who failed asked me to add more points... This is uncontrollable, and the teacher did not force the students, and the students took the initiative to deliver it to the door..."

Ou Ye pinched Shen Qi's waist violently: "Shen Qi, I allow you to organize the language and speak it again."

Shen Qiyi said righteously: "If you want to manage, you must manage it! Other places are not my control, but at Yan University, I must manage it. By the way, the Mathematics Institute has never invited me to give test papers for mathematics students. I haven't produced the papers for several years."

Ou Ye asked: "I remember the tragedy of failing the subject in the number of numbers. In the end, only 30% of the students failed, and you let go of the remaining 50%?"

Shen Qi: "I have added some points to those with real scores of 50 or above. It is not easy for students to study at Yan University, and the questions I asked that time were indeed very difficult."

Ou Ye became alert: "Did you sleep with a female student?"

Shen Qi waved his hands repeatedly: "No, no! All the people who come to ask me for me are male students. The doctoral students I brought are all male students."

"oh."

"Old Qu, let's talk about some serious business and go to your office." Shen Qi asked Ou Ye to go back to the ward first, and he and Professor Qu discussed medical issues together.

After the tolerability test of the new drug phase i clinical trial, it is a test of pharmacokinetics and pharmacokinetics.

Triazaoctenenin has now advanced to the pharmacokinetic and pharmacokinetic test stage. At this stage, the research team studied the absorption, distribution, metabolism, excretion and time process of drugs in subjects through PK, and studied the time process of drug action through PD.

Through pk/pd and related mathematical methods and combined with clinical observation, the phase i clinical data of triazaoctenenone has begun to show clues.

Including Ou Ye, there were a total of 60 phase i clinical subjects.

As Ouye’s husband, Shen Qi is most concerned about the tolerance of triazaoctenol in Ouye, drug coupon/pharmaceutical efficacy indicators.

As a developer of triazaoctenol, Shen Qi also needs to pay full attention to the clinical manifestations of these 60 subjects, including previous animal experimental data and subsequent phase ii and phase iii clinical trials.

Whether a new drug can be launched depends on its safety and efficacy in most target subjects.

Shen Qi of course hoped that triazaoctenen would eventually be launched on the market, and his focus gradually shifted to other subjects.

Professor Qu showed Shen Qi a pharmacopoeia/pharmacokinetic efficacy model established based on 60 subjects. It is currently a semi-finished product and needs to be supplemented with data, but some trends can also be seen.

"tmax, cmax are measured through actual measurements, auc0~t is obtained through trapezoidal calculation method. We use λ2 to find the estimated values ​​of t1/2 and auct~inf. This is a non-atrial model, which is the main pharmacokinetics, bioequivalence, and bioavailability research, and is also the legal calculation method in the application of new drugs."

"However, the parameters obtained by non-ventricular models are sometimes difficult to use to establish a PK prediction model and perform PK/pd correlation analysis, so in this clinical trial, we also used the AV model and conducted rigorous mathematical analysis. Director Shen, you see, this is Sample 6. After the drug enters the body of Sample 6, it is distributed to the target of action, and after combining with the target, it produces pharmacological effects, which causes physiological and pathological changes, thus bringing clinical therapeutic effects."

"The data of sample 6 is very good, who is this?"

"Sample 6 is your wife."

"Oh, it's pretty good, it's quite 6. But sample 27, it seems not ideal."

"Sample 27 is He Yuankai, the university teacher who pretended to be crazy and stupid just now."

"Look at the overall modeling analysis."

"The overall model has not been done yet, but it's okay, look at the process data. Director Shen, we use lc-ms/ms analysis to analyze, within the range we set, the relationship between drug concentration and its signal response is described by a weighted linear regression function, and can also be described by a binomial..."

"Lao Qu, please get out of the way, I'll help you describe it in binomial."

Shen Qi volunteered to take on the work of mathematical model calculation and analysis. More than half an hour later, he completed the binomial description of the overall model.

Comparing the weighted linear regression function description, the binomial description reveals a more detailed relationship between drug concentration and its signal response.

"The Philippine Award winner takes action, it's really different."

The phase i clinical trial of triazaoctenol has reached its final stage. The main work at this stage is data analysis and processing, and finally a written report is formed. The research team and clinical team apply for new drugs or publish papers are all based on data and judged the research results using written reports.

Shen Qi helped Professor Qu make a binomial description, which accelerated the clinical team's data processing progress.

It can be seen from the existing data that taking into account the maximum value, minimum value, mean value, and the hope of triazaoctenen passing the phase i clinical trial is very high.

With the publication of Ou Ye's official paper on "Strong BSD Conjecture", many mathematical teams around the world claimed that they had carried out the explanation and verification of "Strong BSD Conjecture".

These mathematical teams include the Balgava team of the Clay Institute, the Gong Changwei team of Columbia University, the Linden Strauss team of the Weizmann Institute of Israel, the Adama team of the Oxford University, the Su Wenxie team of the Shuimu University, and the Ucla Tao Zhexuan team of the Ucla...

The explanation and verification of "Strong BSD Conjecture" seems to have formed an academic competition.

Well-known mathematicians took action from formal academic institutions in Europe, America and Asia, and civilians around the world were not willing to lag behind.

A retired math teacher at Ouye High School’s alma mater declared on a video website with a huge traffic volume: “After I verified, Ouye’s “Strong BSD Conjecture” is established. There is no need to thank me, this is what I should do.”

It is unfounded to say that the retired mathematics teacher showed several verification manuscripts in the video, which looked very professional.

At the end of the video, the retired mathematics teacher said: "Come to the little genius mathematics class to help your child win the gold medal in mathematics Olympiad, and the success rate of being admitted to prestigious schools is as high as 98%!"

"So it's an advertisement!" Netizens complained.

Some netizens also believe: "Now, training class advertisements require technical content. At least the math teacher's verification manuscript looks very professional."

There are indeed peerless masters like the crouching tiger, hidden dragon, and maybe there are really peerless masters like the sweeping monk.

There is no doubt that Mr. Liu, the instructor of the Pomegranate Mathematics Class of Experiment 2 Primary School, is a master.

Teacher Liu is a Ph.D. in mathematics graduated from Fudan. He is a clerk of the Chinese Mathematics Society and was once the coach of the algebra course of the Chinese Mathematical Olympiad national team.

Teacher Liu has great experience in mathematics competitions. He is a meritorious coach. He has trained many imo full-score gold medal players such as Shen Qi and Zhou Yuan, and helped the Chinese mathematical Olympic team dominate the imo team championship for five consecutive years.

Doctor of mathematics from a prestigious university, a clerk in the Chinese Mathematics Society, and a meritorious coach of the national team of the Mathematical Olympiad... With such outstanding experience, why is Teacher Liu willing to serve as the instructor of the mathematics elite class in a primary school?

There must be shocking secrets hidden in it.

"Shen Nofi, can you solve this equation?" Teacher Liu knocked on the blackboard in the small classroom. He was not a teacher in Experiment 2 Primary School, but a high-paid instructor hired by Experiment 2 Primary School.

There is only one student in the small classroom, she is Shen Nofi.

After arrangements by the mathematics teaching and research group of Primary 2, when a student from Class 1 (2) was taking mathematics classes in Class 1 (2), she would go to the small classroom and receive careful guidance from Teacher Liu of the Pomegranate Mathematics Class.

The equation on the blackboard is, 12-3(9-x)=5(x-4)-7(7-x)

This one-element equation question is the teaching content of fifth grade. For most first-grade primary school students, this question must be beyond the syllabus.

But for Shen Nofi, it is normal to be beyond the rules.

A week ago, this topic went beyond the outline.

Now, under the guidance of Teacher Liu, Shen Nofi has mastered the core technology of the one-center equation.

Chen Nofei nodded and said, "Teacher Liu, I know this question."

Teacher Liu handed half of the chalk to Chen Nofi: "Come on the blackboard, you write the steps to solve the equation. If you give the correct answer, then we immediately enter the teaching stage of multivariate equations."
Chapter completed!