"Qi, when you come to the hospital, please bring me something." Ou Ye called Shen Qi.

Shen Qi looked up the documents in his office and said, "Okay, what are you bringing?"

Ou Ye: "Gauss Notes Volume 15."

"Huh? Do you want to read this book of Gauss' notes?" Shen Qi was a little surprised. The document in his hand was the Phillips-Klein version of Gauss' notes Volume 15.

There are 20 German handwritten notes that Gauss currently live in the world, all of which are kept in German academic institutions and are not for sale. Even Gauss's avatar was printed on the German marks circulated from 1989 to 2001. It can be seen that Germans respect scientists very much, and the currencies of other countries often have the avatars of kings, queens or presidents printed on the currencies of other countries.

Gauss is the founder of the Göttingen School, and Phillips Klein is the descendant of the Göttingen School.

This Phillips Klein is the one who was driven crazy by his good friend Poincaré.

After going crazy, Phillips Klein lost his combat effectiveness in solving mathematical problems. In his later years, he focused on writing mathematical history and translated Gauss' 20 notes into English, French, Latin and other languages.

The English version of Gauss' notes handwritten by Phillips Klein was translated several times and was eventually collected by the Princeton Institute for Advanced Study.

When Shen Qi returned from the United States, he brought back Phillips-Klein's English version of Gauss' notes 15 to 18.

The Germans would not hand over the original Gaussian notes in any form, and the Klein version of Gaussian notes has become an antique artifact today.

In fact, Gauss' notes have been published long ago and are translated by the publishing group into various languages ​​and sold around the world.

But mathematicians who have status, status, some spare money and some sentiment are more willing to collect manuscripts.

Shen Qi's own manuscripts were either given to someone or exchanged with other collectors.

Klein's English version of Gauss' notes 15 to 18 were exchanged for Shen Qi.

Manuscripts and cultural relics from more than a hundred years ago should not have been read frequently, otherwise they would be easily damaged.

It was at the critical moment that Shen Qi took out the manuscripts of scientists in history for review.

He, his wife, and many top mathematicians believe that manuscripts and printed objects not only have distinctions in terms of quality, but also have a spiritual imprint that has not yet been proven but has a faint existence.

"Ok, I'll bring you Gauss' notes later, what else do I need?"

"Auntie's scarf."

"Okay, wait for me, see you in twenty minutes."

Ou Ye’s needs are extremely simple, academic and physiological.

As required, Shen Qi took Gauss' notes and aunt's towel to Ou Ye's ward.

"So my wife, are you going to cut from the Gaussian quadratic domain into the rank greater than or equal to 2?"

"Well, I think it's possible. Qi, what do you think?"

"I think it's possible, so do it."

Shen Qi suddenly felt very complicated.

Ou Ye couldn't find mathematical inspiration at home, and even fainted.

Once hospitalized, Ou Ye seemed to have entered a higher academic level.

Shortly after Shen Qi left the hospital, some new reports were reported in the international chemistry community.

A research team from the University of California, Berkeley said that they successfully synthesized a macrocyclic compound with 20 chiral centers in the laboratory, with the number of isomers of 2 to the power of 20.

"So fierce?"

This is Shen Qi's first reaction after seeing this report.

The Berkeley research team pointed out in the report: "We refer to the macrocyclic compounds research results of Yanda Shenqi's team and synthesized the macrocyclic compounds with the largest number of chiral centers to date. The use of this macrocyclic compound still needs further research, but we have made historic progress in the structure of the new compounds."

The research team of the University of Tokyo said that they synthesized a new macrocyclic compound with extremely complex structures in the laboratory. This new compound is similar to the chemical structure of anemone toxin, the difference is that it has a macrocyclic structure of more than eight elements in key parts.

The research team at the University of Tokyo also thanked Shen Qi's team for providing the macrocyclic compound theory a few months ago. They called the new compound "lighthouse jellyfish hormone", which they said helped to reveal some mysterious problems in nature.

Research teams in Germany, the United Kingdom, and Australia also reported their latest research progress on macrocyclic compounds. They proved through experiments that the theory of macrocyclic compounds and new rearrangement reactions proposed by Shen Qi's team is very reliable.

"This...this is a bit out of control."

Shen Qi didn't know whether to be happy or worried.

He proposed the theory of macrocyclic compounds. After this theory was introduced, various fancy new products were derived from the hands of chemists from various countries.

It is difficult to judge for the time being that the actual impact of the fancy new compounds may have.

Shen Qi's intuition told him that the emergence of a large number of new macrocyclic compounds is a double-edged sword. If it is used well, it will benefit mankind and destruction of the world.

System: "The host completes the task of chemistry promotion level 14, upgrade!

Conditions for chemical promotion level 15:

160 million points of academic top score;

2. Use chemical means to reveal a mystery.”

No matter what, it is always worth being happy that Chemistry has been promoted to Level 14.

Mathematics and physics are promoted to level 14, and they are all point-by-point.

The system requires Shen Qi to solve some specific mathematical and physical problems so that Shen Qi can be promoted to level 15.

Condition 2 for chemical promotion level 15 is open and needs Shen Qi to explore it himself.

Yanda People's Hospital.

All tolerated administration of triazaoctenenin was completed.

A team of research physicians led by Professor Qu processed clinical data such as individual number, mean, median, standard deviation, coefficient of variation, geometric mean, geometric standard deviation, etc. through statistical methods.

Combined with clinical observation and data analysis, Professor Qu's team believes that triazaoctenol has passed the tolerability test, and all subjects will enter the pharmacopoeia/pharmacoefficiency test stage next.

Many literatures have reported that the success rate of new drugs in the clinical research stage is around 10%, that is, only one of the 10 candidate drugs can be finally launched.

Research shows that the main reasons for the failure of clinical development are effectiveness (66%) and safety (21%).

A drug has good safety and will not cause serious side effects if taken. It is the most basic requirement.

The core indicator that determines whether a new drug can be launched is effectiveness, that is, the effect of the drug in treating patients.

In order to avoid the failure of drugs with high R&D expenses in the phase iii clinical trial stage, in phase i and ii clinical trials, a proof of concept based on effectiveness must be carried out to eliminate drugs that are not easy to develop successfully as soon as possible, so as not to waste money.

Based on the above clinical trial ideas, Ou Ye finally took triazaoctenin again.
Chapter completed!