"Laoyan, if you continue to perform double nitrolation of c01a, what will you think of the next product?" Shen Qi asked.

Lao Yan said: "In theory, the core structure of benzoazazaz? contains two functional groups of amine and aryl in a very close position, so I speculate that under the reaction conditions of electrophilic substitution, the electrophilic attack on the aromatic ring is protected by carbamate and amino groups, and even strong nitrification reagents are difficult to nitrate the aromatic ring. That is to say, the next product is meaningless."

"Simulate it." Shen Qi operated the computer and used sybyl software to simulate it.

The latest version of sybylpro is a computer-assisted drug design software that is based on existing databases to assist in drug design, chemical combination solutions and other operations.

The simulated target product is a derivative of benzoazacea, and the most matching commercial drug in the database is carbamazepine tablets.

Carbamazepine tablets are mainly used for symptoms such as analgesia, epilepsy, mania, psychosis, diabetes insipidus, etc., and are central nervous system drugs.

Lao Yan looked at the computer screen and said, "Is the next product of c01a meaningful? Is it meaningless? Is this thing used to treat mental illness?"

"It's really meaningless to imitate carbamazepine, but this is an auxiliary software after all, and it can't make 100% accurate predictions. I feel that the next step of dual nitrolation is of scientific research value. Just try it. Experiments are continuous attempts. Maybe the blind cat will catch a dead mouse and will be lucky." Shen Qi insisted on dual nitrolation and began to prepare raw materials.

The boss is so stubborn that Lao Yan has no choice but to do the pre-experiment with Shen Qi.

The preparations took place for a whole day, and the raw materials had to be re-formulated and synthesized.

The next day, the experiment began, codenamed c01b.

Shen Qi and Lao Yan went on battle together, and trifluoroacetamide protection was specially introduced to isolate nitrogen atoms, and by dispersing the electron cloud density on nitrogen, preventing the formation of double-substituted cation intermediates.

This protection further causes the nitration reaction to occur. At the same time, Shen Qi added the strong nitration reagent nitrotrifluoromethanesulfonic acid, which is specially used to overcome the slow nitration of benzoazacea derivatives.

Two days have passed at this time, and Shen Qi and Lao Yan are on duty at any time in the laboratory.

Finally, the dinitro compound condensed with sodium glyoxaldehyde to obtain quinoxaline, and deprotection obtained the target product.

The target product is a light blue crystal, crystal clear, beautiful with magical colors.

Shen Qi and Lao Yan were fascinated by its dreamy appearance, and the hard work of a few days was not in vain.

"The charm of chemistry lies in this, a pile of toxic raw materials, which eventually created an incredible beautiful product." Lao Yan covered her tightly from her toes to her head, and there was almost no inch of bare skin on her body.

Shen Qi, who was also fully armed, focused his attention on the target product and said: "Just looking at the appearance alone, c01b is more than one level higher than c01a. This thing is not used as a medicinal product, and it can be sold as a jewelry for a lot of money."

Both Shen Qi and Lao Yan know that for chemical products, appearance is important and efficacy is more important, that is, the inherent properties of chemical products.

Through chemical methods such as nuclear magnetic resonance and molecular weight determination, Shen Qi and Lao Yan determined the molecular formula, molecular weight and molecular structure diagram of c01b.

"So, its name is 4-oxidation-5-phenyl-1,3,4,6-tetrahydro-6,10-methylene-2h-1,4-benzoazacea?, match it in the database, what is the closest commercial drug to C01b?" The matching result given by ybyl is: carbamazepine tablets.

"No, why is it another carbamazepine film? The database has not been updated?" Lao Yan felt that the computer was fooling them.

"Check the latest papers on organic chemistry and medicinal chemistry." Shen Qi made a suggestion that he needed to know the roughly pharmacological properties of c01b, otherwise it would be very blind to do animal experiments without targets.

After consulting a large number of literature and consulting two senior professors from the School of Chemistry and the Department of Medicine, Shen Qi came to speculation that the main function of c01b should be to regulate the dopamine secretion in the nucleus accumbens region in the midbrain limbic dopamine system, which is the basic mechanism of nicotine addiction.

Shen Qi laughed: "Chemistry is an interesting subject. The c01a you made from Lao Yan and you got after double nitrolation of c01b should theoretically be a chemical test product to restrain smoking addiction. Who can you spare me? You smoker, you accidentally made a new smoking cessation compound!"

"Damn?" Lao Yan was shocked. Will he pay it back sooner or later when he came out?

Shen Qi's wording is very rigorous. He has been saying that c01b is a chemical test product. In theory, it has the effect of quitting smoking, but he does not say that it is a drug.

The c01b obtained in the initial laboratory test can only be regarded as a chemical test product. It can only be called a chemical commodity after passing various properties tests, which is verified to be safe, effective, and finally commercially produced.

Drugs and chemical products that are clearly marked on the market are all chemical commodities, and the commodities mean that they have been widely recognized by people and are willing to pay for them.

To develop a new non-computer commercial drug, many scientists need to invest a lot of effort and go through long experimental research and process verification before it can be put on the market and benefit mankind.

Shen Qi and his team had three guns, one of which was mainly responsible for raising animals and dissecting animals. The only people who were actually engaged in innovative research were Shen Qi and Lao Yan.

Shen Qi said: "I think this c01b has the potential to be commercialized. As far as I know, there are not many real quitting drugs on the market. The quitting rate of nrt quitting gum is only 20%. The agonist quitting drugs of nicotine acetylcholine receptor have a high success rate of quitting smoking. However, smokers use this drug and smoke quitting, but they have a certain addictive dependence on quitting drugs."

"It is difficult to quit smoking. If someone who can make up his mind to quit smoking, what are you afraid to do? " Lao Yan appeared and said, subconsciously touching the cigarette.

"Are you addicted to smoking again?" Shen Qi smiled.

"I'll go out to smoke, go out to smoke." Lao Yan's cigarette box was a habitual movement, but the cigarette was not on his body and was locked in the storage cabinet outside the laboratory.

Shen Qi and Lao Yan came outside the laboratory together and took off their masks and protective goggles.

Lao Yan found Shen Qi looking at him with a mysterious smile. He shivered and felt chill and fear: "Boss, I can't quit smoking addiction. Don't use me for human experiments!"

Shen Qi patted Lao Yan on the shoulder: "Making a brand new commercial drug is a very difficult and long job. If you cannot fully utilize external resources, you, I, Lao Tu, cannot produce commercial smoking cessation drugs. As for clinical trials, how could I do it on you? The person I least want to mess with is a chemist. Today I will use you for the experiment, and you might poison me to death tomorrow."

"Chemistry workers also have to abide by the law, right?" Lao Yan said, and asked again: "What should I do next?"

Shen Qi said: "There are more than one billion smokers around the world, and more than half of them have the desire to quit smoking. The c01b project is left to you to follow up. You can study it in depth, collect more data, and then start animal experiments."

"Then you have to hire me some assistants. Even in the initial stage of the laboratory, I am still struggling alone. You are very busy and you cannot squat in the laboratory all day long." Lao Yan requested.

"You will publish a few articles first. If there is no scientific research result, why should I ask for someone?" Shen Qi said, and then asked with concern: "How are you doing with Xiaolian?"

Lao Yan talked about the matter: "If you don't add labs to me, I can only stay in the laboratory. How can I get time to pick up girls?"

"Oh, I've been soaked in this, okay, Lao Yan, keep working hard. The experimenter is not in place so quickly. You can hold on first, experiment during the day and pick up girls at night, the pace is very good."

Shen Qi and Lao Yan came to the third floor. Shen Qi pointed to a vacant small room and said, "From today, this is a smoking room. You can buy a cigarette butt recycling equipment with ventilation, which is the kind of equipment in the airport smoking room. After buying it, you can ask for financial reimbursement. But I still hope that you can quit the cigarette."

"Okay, okay, long live the understanding." Lao Yan was overjoyed, so he found a cup of water to catch some water, and squatted in the empty house and started smoking.

Shen Qi came to the cafe and sat down to have coffee.

There are not many people in the cafe, which shows that the center staff is very busy.

Shen Qi saw Wei Teng, Zhou Yu'an and Xiao Junlong sitting together chatting with joy on a table.

Holding up the coffee cup, Shen Qi walked to the table of the three of them and sat down: "It seems that the n-s equation project has made significant progress?"

"Not that fast." Zhou Yuan shook his head.

"Then you laugh so happily?" Shen Qi asked.
Chapter completed!