With Zhao Xueyan's current brainpower, I recalled the huge information chains I received before traveling through time, and wanted to find a way to make a fortune in Hong Kong Island...

In fact, it is very simple. A-go business is OK? The current Hong Kong society is gradually becoming richer. Various brand-name clothes, women's bags, shoes, etc. are popular all over the world, but how many people can afford genuine products?

If you control a clothing factory and shoe factory to do A-products, the profit will be almost a mountain of gold and silver, but this is not very suitable. This kind of business requires support from the community, or it is almost a gold and gold that belongs to the community alone.

He is still on the way to clear his grievances. He has too much trouble to engage in A-go products. He can't fight with the clubs and gangs at any time.

Putting aside this idea, there are as diverse ways to make money, or are the famous Wanglaoji and herbal tea drinks? This is a century-old store and it became famous in the late Qing Dynasty. It seems that the brand and formula are in the hands of Guangzhou Pharmaceutical Group.

Isn’t the battle between Wanglaoji and Jiaduobao, which was famous in later generations, just because of the brand?

Now in 1986, it will not be until 1992 that Guangzhou Pharmaceutical produces boxed and canned herbal tea.

Choose Wanglaoji and go to the mainland to discuss business with Guangzhou Medicine? How to solve this... identity problem?

How about abandoning Wanglaoji and choosing a Wahaha? How about Master Kong’s instant noodles? This only rose in the late 1980s or 1990s.

Su food and beverages are full of gold and silver seas.

Mineral water, black tea and green tea beverages, Jianlibao, etc. As long as you know how to operate advertising, such as sponsorship advertisements for the Asian Games, or drinking Wanglaoji for fear of getting angry, drinking Wahaha, and eating delicious food, etc., you can sing the advertising slogans that are smooth.

It's really not difficult to create the first foundation.

The initial funds can be found in the mahjong hall and casino. It is said that he has easily raised more than 100,000 yuan through small gambling these days, which is a real record.

You should know that in normal history, Wahaha Group, also known as a school enterprise, in 1987, Boss Zong borrowed more than 100,000 yuan to start a business with two retired teachers. The output value exceeded 100,000 yuan in just three years. The biggest convenience is accuracy in positioning and advertising bombardment.

The difficulty is that he doesn’t have an ID card. He has a Stanley household registration in Hong Kong Island, but when he returns to the mainland... he is a bigger black household!

After thinking about it, Zhao Xueyan felt that he had such a small tragedy at the moment.

"There are many ways to make money. Whether it is fast or slow money, I have a lot of money in my mind, but if the identity problem is not solved, how can I get started?"

"Even if I want to overtake from my old business, it's super troublesome."

What is Zhao Xueyan’s old profession? In fact, it is medicine. Before he traveled through time, he studied at Huaxia Pharmaceutical University and was a sophomore.

It is of course nonsense to ask him to develop a new drug from scratch. He can't resist the fact that he can overtake. Speaking of bomb-level drugs in the history of the pharmaceutical industry, the name Humira cannot be avoided.

Its Chinese name is adalimumab, or Xiumeila.

Where is this blockbuster bull? Traveling through the pre-economic era, global sales of 19.9 billion US dollars in 2018, 19.6 billion US dollars in 2019, and 14.6 billion US dollars in the first three quarters of 2020.

Since its launch in 2002, it has easily sprinted toward accumulative sales of 200 billion yuan by 2020.

His expertise is there, and he is familiar with all kinds of knowledge points of the world's best-selling blockbuster Humele.

Xiumeile was specially used to treat rheumatoid arthritis. Before Xiumeile appeared, countless rheumatologists around the world were helpless in the erosion of the disease on human joints.

In the 1950s, a drug appeared, steroid hormones such as cortisone, which had amazing therapeutic effects on rheumatoid arthritis. However, in countless patients, nightmares followed, and steroid hormones such as cortisone, which would cause patients to have serious effects such as osteoporosis and diabetes.

Those side effects are even more terrible than rheumatoid arthritis alone!

Cortisson then withdrew from the stage of history.

In the 1967, a new NSAID drug emerged, once again bringing a carnival to patients with rheumatoid arthritis, but side effects such as renal failure and gastrointestinal damage once again defeated countless people's dreams.

Until the early 1980s, when Mark Feldman, an immunologist in Kangaroo Country, studied a disease that could cause hyperthyroidism, he found that some thyroid cells overexpress a type of molecule that can activate immune responses. Behind this increase is the stimulation of cytokines.

Mark Feldman made a bold hypothesis that perhaps it is the cytokines that trigger autoimmune diseases.

In order to verify this idea, Feldman looked for patients with various tissues and could not find enough lesion tissues in patients with hyperthyroidism. He searched from other patients with similar diseases and found rheumatoid arthritis.

Because of this impotent disease, doctors and experts will often directly remove the patient's diseased tissue to relieve the patient's symptoms.

Feldman led a research team to confirm that a large number of pro-inflammatory cytokines appear in the joints of patients with rheumatoid arthritis. When these factors appear, the patient's immune regulation mechanism is out of control.

Based on this principle, Feldman and his research team began to study the treatment of rheumatoid arthritis. Animal experiments showed that IL-1 is the potential cause of rheumatoid arthritis. So, which cytokine triggers IL-1?

If it can be found and inhibited by inhibiting this cytokine, wouldn’t it be equivalent to restraining IL-1 and even more restraining the patient’s condition?

The outside world is not optimistic about the therapeutic potential of this single cytokine targeting, but Feldman and other professionals have finally proved that as long as TNF-α antibodies that inhibit various cytokines can be cultivated, he can almost completely inhibit the production of IL-1.

Blocking TNF-α with TNF-α can greatly alleviate the symptoms and conditions of rheumatoid arthritis.

In terms of animal experiments, this new drug went smoothly. It was very good to inject TNF-α antibody into the sick mice. The only problem is that antibodies from the guinea pigs are not suitable for the human body and have many side effects.

Until the early 1990s, many people-mouse chimeric antibodies developed by companies had very average treatment effects.

It was not until the birth of the entire human TNF-α antibody that the finished product Xiumeile was found.

It has benefited countless patients with rheumatoid arthritis around the world.

In the late 1910s, Xiumei Le was the biggest hit among the bombshells in the pharmaceutical industry!

It is now 1986, and Mark Feldman's bold assumption has long been established. He may have also studied the TNF-α antibody of diseased mice, but it is plagued by the mice that the antibodies are not suitable for humans.

The birth of all-human TNF-α is closely related to the phage display technology in the biomedical community.

In 1985, Professor Smith pioneered the bacteriophage display technology, and with this technology, he won the 2018 Nobel Prize in Chemistry.

In the 1990s, Professor Winter optimized multiple processes of phage display and successfully obtained a fully humanized antibody from the TNF-α antibody of the mouse.

This involves the isolation technology of the variable region encoding genes of human antibodies.

This all-human antibody is named D2E7.

This is Xiu Meile!

Now in 1986, TNF-α antibody should have a version of the diseased mouse, and Smith also has a phage display technology pioneered by him. As long as you learn from Professor Winter and optimize multiple processes, you can create Xiumei Le.

It will be launched globally, with cumulative sales of over 100 billion US dollars in the next decade, and will become a new generation of global drug kings in the global pharmaceutical industry.

If Professor Winter's achievements are confiscated by relying on his superficial brain power, Zhao Xueyan is the medicine god for rheumatoid arthritis patients around the world!
Chapter completed!