none

Chapter 361

human trials

"No, I can't die!"

Suddenly, Mark suddenly opened the quilt on his body, once again put on the patient's robe and slippers, and gently opened the door of the ward.//www.//Just like last time, on the corridor of the special ward

There was no one around. He looked around and saw that the nurses in the nursing station seemed to be busy. If there hadn't been a bell ringing, obviously they wouldn't have noticed him.

Holding on to the wall of the corridor, Marko staggered towards the fire stairs. A few minutes later, Marko, who was breathing heavily and suffering from a low fever, walked out of the hospital, stopped a rickshaw, and left.

He directly reported "Yaxin Medicine". Although the low fever made his consciousness a little cloudy, he knew that he was the only one who could save himself now.

"Chemotherapy!"

As Marko sat on the tricycle, a new medical treatment method pioneered by his mentor when he was studying in Germany kept popping up in his mind.

At the turn of the 19th century and the 20th century, it can be said that there are new inventions every moment. This is an era of explosion of inventions, and the same is true for the medical industry. In this era, Paul Ehrlich was the most famous

The person who attracts the most attention in the medical science community is Eulich and his colleagues. Seven years ago, after long-term experimental research, they screened hundreds of newly synthesized organic arsenic compounds and finally determined that the 606th compound had anti-syphilis properties.

Activity, this is the first organized and purposeful attempt to achieve optimized biological activity through chemical modification of the lead compound. It has specific effects on syphilis and other spirochete diseases, and is relatively safe. Although the side effects of either 606 or 914

They are all too big, but these drugs have created a precedent - chemical treatment.

Eulich and others had discovered chemical treatments for several diseases, such as trypanosomiasis, caused by protozoa; or, like syphilis, caused by unusual bacteria. For more

Common and microscopic bacteria are beyond the reach of purely chemical treatments.

Just like the bacteria that Mark Duo is infected with now, they are the bacteria that cannot be treated by the two drugs. However, as early as last year, in order to continue research at the Paul Ehrlich laboratory in Germany, Mark Duo began to use the company's funding to continuously

He tried chemical treatment, and the wide variety of chemicals in Lianyungang gave him sufficient raw materials to conduct chemical treatment experiments.

For example, Republic Dye Company has launched hundreds of various dyes in the past year. In Marko's experiments, he used almost every known compound, so that his laboratory sometimes needed

Hundreds of test mice were sent to the incinerator. Those test mice were either poisoned by the compound or died of various bacterial infections.

Obtaining test data through extensive trials is the only way to develop drugs in this era. Among those trials, some have made certain progress, such as a compound called "Orange 36", which is

A new type of synthetic dye.

Before Marko was admitted to the hospital, he injected "Orange 36" into infected mice. The test results were promising. It could kill streptococci. Although before further testing, Marko was hospitalized.

He entered the hospital, but at this time, "Orange 36" was his life-saving straw.

Although it is still unclear about the pharmacology of "Orange 36" or even whether it has a therapeutic effect on the bacteria he is infected with, in any case, in Marko's view, this may be his last chance.

"Professor Ma, what's wrong with you?"

When Xiang Songmao, who was about to visit Marko in the hospital, saw him outside the gate, he greeted him quickly and hurried over to pay for his tricycle fare. He could guess something from the hospital gown he was wearing.

"Manager Xiang, I'm here to save my life!"

After Mark Duo, who was always sociable, left Xiang Songmao, who was a little confused, after saying this, he walked straight into the research institute of the big pharmaceutical company.

As soon as you enter the laboratory, you will be greeted by the familiar smell of compounds, and in the cages in the laboratory, there are also white mice used for experiments. Among them, the bodies of more than a dozen white mice are slightly red, which is because they have been injected with "

Orange 36" compound white mouse.

In the past few months of experiments, Marko injected a small amount of streptococci into the abdominal cavity of mice. The streptococci reproduced at a rate of one generation in 20 minutes. Within a few hours, the abdominal cavity and blood were filled with streptococci. Within 48 hours, the mice

All died of sepsis. After hundreds of experiments, Marko and his students finally discovered a compound named Orange 36-4 that had no antibacterial effect in the test tube.

-

Sulfonamide

–

2,4

– The hydrochloride of diamine azobenzene is extremely effective against mice infected with streptococcus. However, its disadvantage is that it dyes the mice bright red.

A white mouse with a slightly red body was caught from the cage. It was obvious that the dye was slowly fading away. This mouse, like other mice, had been injected with diamine azobenzene hydrochloride. They did not die.

In sepsis, even the streptococci in the body have been killed.

What does it do?

Marko didn't know this clearly. His hot body and increasingly blurred consciousness reminded Marko that he didn't have much time. According to the fatal mechanism of bacteria, he still had at most one day, which meant that he had no time at all.

For further research, you can only test it on your own body.

"Try it!"

Picking up the test report on the table and looking through the report, he found that even though he was admitted to the hospital, his students still conducted the test seriously. They studied the toxicity of Orange 36 and the tolerance of mice and rabbits.

The dosage is 500mg

kg body weight, larger doses can only cause vomiting, indicating that this compound is very toxic.

"500mg per kilogram, my weight is..."

After weighing himself, Mark Duo received an injection dose of 30,000 mg. To be on the safe side, he increased the dosage. After the bright red dye was sucked into the syringe, Mark Duo tied his arm with a tape and then inserted the needle into the vein.

Blood vessels, slowly injecting, watching the bright red dye injected into the body, he just felt so nervous that he was suffocating. This was the last choice. Can this compound kill the bacteria in his body?

"Teacher, you..."

Just after he injected the last compound, his student Wei Fangping walked in.

"Fang Ping, you take the record, inject compound: 4

-

Sulfonamide

–

2,4

– Diamine azobenzene hydrochloride, injection test body weight is 55 kg, injection dose: 50000 mg..."

Facing the students, Marko, who was holding back the feeling of vomiting, began to talk about the test data and his feelings after the injection. At this time, he completely forgot that he was saving his own life, but devoted himself wholeheartedly to the experiment.

Regardless of whether it is successful or not, at least first-hand human trial data can be obtained.

As time passed, Wei Fangping took the teacher's temperature every half hour. In the first three hours, his body temperature did not show any downward trend. At this time, Marko even had some consciousness due to the high fever.

Fuzzy, but he still kept spitting out his feelings.

"Test subject three hours after injection..."

While talking, after taking a sip of tea, Mark Duo could feel that his mind seemed to be more comfortable than before and no longer as tense as before.

And the body temperature seems to have dropped a bit, which should be an indication that my body is developing for the better.

"How about it?"

Looking at Marko lying on the bed through the glass window, Xiang Songmao rubbed his hands nervously. Professor Ma was experimenting on himself. Although he was saving his own life, he couldn't help but worry about him.

"The body temperature has dropped. The specific effect is not yet clear. I hope it will be effective!"

Time passed by, and slowly there were more and more people in the corridor. Almost everyone in the institute knew that the director of the institute, Professor Mark Duo, was conducting experiments with his own body, and the process of the experiment was really shocking.

People were worried. In the past few hours, Professor Makto had been vomiting.

"Five hours after the test, the second injection was carried out, and the injection dose was doubled!"

A few minutes later, at Marko's strong request, his student and assistant Wei Fangping began to give him an intravenous injection. At this time, his appetite had gradually recovered, and he stared blankly at the honey in his palm.

Cake. Although he had no appetite, he still reluctantly brought the cake to his mouth. Suddenly, he felt nauseated and uncomfortable.

"vomit……"

Covering his mouth where he wanted to vomit, Mark rushed to the toilet in the ward and vomited in the washbasin. The vomit was full of gastric juices, and he finally finished vomiting. He rinsed his mouth with water, turned on the light in the bathroom, and opened his eyes in surprise.

My eyes widened and I looked at myself in the mirror. Why is my face so red?

At first, he thought it was an illusion, but when he looked closer, his face was indeed red, which was obviously caused by the dye injected into the body.

"I didn't expect that I would become famous now?"

Panting, Marko spoke intermittently, but unlike before, he already felt much lighter all over. At least he no longer felt as heavy as he did a few days ago.

Lying on the bed again, Mark closed his eyes and thought over every sentence in the test report. Although he still couldn't figure out the mechanism of action of this compound on bacteria and what substances in it could kill bacteria, he

But I feel that the medicine has taken effect in my body and has successfully prevented the further spread of bacteria.

Thinking of this, his heart beat wildly like a big bell, and suddenly he was no longer as afraid of death as before, but full of confidence in this medicine.

"If it is cured, we must study this drug carefully."

Although it is only a trial, Marko knows that if this trial is successful, this drug may change the entire world. By then, millions of people around the world may be saved because of this drug, especially in today's world.

During the war, during the "Jiao'ao Incident", thousands of soldiers died from bacterial infections in their wounds. If this drug could save him, it could save others.

Through the window, looking at Marko in the room, Xiang Songmao looked at him intently. He could see his fluffy hair and his thinking eyes under his broad forehead. Although his face was abnormally bright red. But this would have anything to do with it.

Everyone can notice that Professor Ma's body is getting better, which means that the medicine has taken effect.

"If successful, this drug could change the world!"
To be continued...