Beijing,

Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences.

An accident two months ago cast an indelible shadow here. Although there were no casualties, it caused irreparable economic losses, even though China is world-recognized in the field of crispr-cas9 gene editing.

leader, but this technology still has serious flaws.

How to make up for this shortcoming has become a task to be completed by the Institute of Biochemistry and Cell Biology of the Academy of Sciences. Although crispr-cas9 gene editing technology has quickly become the most popular technology in life sciences due to its simplicity, efficiency and diversification.

Especially for gene therapy related to human diseases, it is hailed as one of the most potentially transformative innovations in modern human medicine. However, behind the success is often the accumulation of failures. The accident two months ago was the most

Good explanation.

a certain department,

Silence has always shrouded this office. A dozen of the top researchers in the industry are having headaches over upgrading the CRISPR-Cas9 gene editing technology. A whole month has passed without any results.

Regarding the research on regularly spaced clustered short palindromic repeats, many people present were elites, but how to upgrade it stumped everyone, including many PhDs.

at first,

Everyone's goal is great, to establish an existence that surpasses the CRISPR system. However, with continuous in-depth research, it is gradually discovered that the cruelty of reality has exceeded everyone's imagination. The CRISPR system cannot be surpassed at this stage.

Fine optimization is carried out on the basis of the original.

However, the CRISPR system has developed from the 1990s to the present and has been upgraded by countless biological scientists. It has reached the point where it can no longer be optimized. At present... the CRISPR system has entered a bottleneck period. If you want to break through...

Unless there is a completely new theory.

Just like physics, the span from classical physics to modern physics is hundreds of years, and modern physics to new physics is still an unknown. Biology has just experienced a huge revolution. When the next revolution will begin is as unknown as physics.

"well..."

"It's so difficult!" A doctor in the office sighed, his words full of helplessness: "The whole world knows that the main challenge in the standard CRISPR-Cas9 system is to reduce the probability of missing the target, but who can do it? Even if it is done,

...It is equivalent to borrowing the shell of the crispr-cas9 system, and the content inside will change."

"Then what are you going to do?" The sullen middle-aged man sitting next to him said with a wry smile: "If this problem is not solved, we may be severely cut in funding. After all, this incident has left a huge shadow.

"

for a time,

Feelings of helplessness flooded into the hearts of everyone present. This problem was not a sporadic difficulty. Unless a genius like Xu Mang appeared, there would be no hope of success.

Xu Mang?

Many people thought about what happened just a few days ago, about artificial intelligence that predicts the three-dimensional structure of proteins from amino acid sequences. It was said that if Professor Xu Mang develops a similar AI, it can simulate the modification of target sites.

"well?"

"Do you think... if Professor Xu Mang suddenly designs a gene editing AI one day, will there be a world-class biological revolution?" The doctor said curiously: "I think it can... At present, in terms of protein structure

, has caused a huge response.”

"Disaster!"

"It's hard!"

"I think the CRISPR system is already the most perfect existence and cannot be surpassed in a short period of time." The middle-aged man smiled bitterly and said: "This kind of idea is different... After all, Professor Xu Mang is engaged in physics, and he accidentally performed in other fields.

But as for gene editing... I don’t think it’s possible!”

While everyone was discussing this matter, Academician Zhong walked in and said to everyone present: "Ahem... be quiet for a moment. I am here to announce two things."

The words fell,

The office fell into silence. Everyone looked at Academician Zhong standing at the door with a hint of doubt in their eyes.

"First of all, I won the right to use the artificial intelligence 'Xuman System' that predicts the three-dimensional structure of proteins from amino acid sequences." Professor Zhong said: "The system will be installed in the near future. In the future, everyone can use this technology to conduct research.

The study of protein structure.”

"Second...Professor Xu Mang has accepted my request to help us achieve a new upgrade in the field of gene editing." Professor Zhong said: "However...I hope that you will not be disappointed because of Professor Xu Mang's joining.

Start to relax, but you must still go all out."

"???"

"???"

"???"

He...he's really here?

Hearing Academician Zhong's words, many people were surprised and endlessly surprised, but then they began to question, not about Xu Mang, but about his own strength.

It's quite tragic to say that I have to take the exam to be a physicist to save the day. This...did I learn biology in vain?

"In order to mobilize your enthusiasm, uh... your entire team will compete with Professor Xu Mang to see who can be the first to complete innovative work in the field of gene editing." Academician Zhong smiled and said: "He is only one person, but you are

There are about ten of them, so there shouldn’t be any problem, right?”

No problem?

This is not a small problem!

In the past, everyone was so confident that how could one person fight against a team of more than ten people? But now...I'm sorry, I can really fight against it! And it's not just against a team. Not long ago, Xu Mang just used

One person suppressed nine American AI teams.

It is conceivable that

It's not right to defeat many with less... It's not right to fight one against a hundred... It should be one person who can guard the barrier, and ten thousand people can't open it. This is Professor Xu Mang.

"Academician Zhong...you are kidding." The doctor said: "Various deeds tell us that no one who competed with Professor Xu Mang ended up well. I don't think we can do it. This is not a confrontation of magnitude at all.

"

"We lost before we even started?" Academician Zhong said helplessly: "Cheer up, everyone. We can't rely solely on Professor Xu Mang. What if he fails?"

The words fell,

Academician Zhong left and on the way to his office, he met a colleague, Academician Chu, an expert in bioinformatics.

"Old clock?"

"I heard that you went to Fuda?" Lao Chu asked curiously: "I remember you went yesterday, right? Why did I meet you here today... this morning? Did you rush back overnight?

"

Academician Zhong smiled bitterly and said: "Yeah... we haven't solved what happened two months ago. We hope to summarize the relevant experience based on a previous mistake, and then strive for a breakthrough in this field, but breakthroughs are so simple.

"

"so..."

"You found Professor Xu Mang?" Lao Chu said with a smile: "How is the situation? Has he agreed?"

"Promise."

"At the same time, I also got the right to use the 'Xu Man System'." Academician Zhong said: "By the way, Lao Chu... What do you think is the probability that Xu Mang will break through the existing framework in the field of gene editing?"

"have no idea."

"Don't ask me this question." Lao Chu said bitterly: "I won't say anything about him..."

"..."

Academician Zhong said helplessly: "Is it necessary to be so cautious? The probability of being able or not is only 50%. How difficult is it to give an accurate explanation?"

"It's not difficult!"

"But if the other party is Xu Mang, it will be difficult... You should understand what I mean." Lao Chu said seriously: "Even though he is engaged in physics, he can do everything, and he is also very proficient in everything.

This is totally unreasonable.”

Academician Zhong smiled: "Tell it to your department and help the molecular biology department make breakthroughs in the field of gene editing."

"good!"

"Are you planning to have a competition with Xu Mang?" Lao Chu asked.

"almost!"

"I want to see how far the researchers in our department are from Professor Xu Mang." Academician Zhong said: "Professor Xu Mang's job is physics, and they graduated from biology. These two

Don’t you want to know how big the gap is between them?”

Lao Chu opened his mouth, and unspeakable words were stuck in his throat.

to be honest...

Don't want to at all!

...

magic city,

Yang Xiaoman and Xu Mang were shopping hand in hand. In fact, Xu Mang didn't want to go out. It's such a cold day... and the cold in the south is different from the cold in the north. The north is a physical attack, while the south is a magic attack. With

Moisture... can lead to rheumatic bone disease in old age.

"well..."
To be continued...