"Professor Yang, I looked at your indicators and the requirements were very low." Wang Xiaoshu brought many experts, all of whom frowned.

The establishment of the Clinical Experimental Center of Hedong University is actually a bit sudden for the academic community.

So much so that scholars outside Yang Rui's laboratory do not know the specific situation of sildenafil.

Normally, it takes at least three or five years for such a large project from the establishment to the implementation, not counting the previous various blowout times.

How long did Yang Rui use it?

From the exposure of the wind to the establishment, it only takes dozens of days.

Concentrate other people's months into days, and the money spent is hundreds or thousands of times the amount of other scholars. This is the majesty of Nobel Prize Yang Rui.

Speaking of which, some of the great scholars who returned to China around 10 years also need 10 billion yuan in funding, but there is actually a gap with Yang Rui, who now needs hundreds of millions of dollars in funding.

Therefore, even if you collect money from several major banks in the Industrial and Agricultural Construction Association, even if you can't afford to offend the bank, even if you are the experts invited by Wang Xiaoshu, you are still careful. Even if you find obvious loopholes, you still dare not question them easily, and your tone of speaking is like a discussion.

"We don't think sildenafil is doing very well..."

"Historically, if we want to pass the US FDA certification, the data may not be enough."

"Although it is clinical stage II, the efficacy still seems to be not significant... Of course, we did not do a complete calculation, but the indicators are obviously a bit low."

Several experts looked like students asking for advice, and their tone was so weak that Wang Xiaoshu wanted to hit someone.

Fortunately, there is no strict superior and subordinate system in the academic community, so what should be said is finally said.

Although it has no momentum.

Yang Rui looked more like a student from the outside. The handsome college brother smiled handsomely, but what he said made people want to beat someone: "My requirement for sildenafil is not to reduce blood pressure, but mainly because of its mechanism of action. This is a completely different antihypertensive drug. Its mechanism of action is different, and it can play different roles for different groups of people."

The classification of antihypertensive drugs is based on the mechanism of action.

Anyone with olol after the drug name is beta blocker, such as metoprolol, bisoprolol, and propranolol; those with dipine are calcium antagonists, and those with priligy are angiotensin-converting enzyme inhibitors...

Including the latest developments, there are six major categories of antihypertensive drugs, and the main force is four of them. If sildenafil is successful, it will be a new type, and its value lies in this.

According to the US FDA's new drug marketing requirements, the new drug is either a pure new drug of different types or a second-generation drug with better efficacy.

It is naturally not easy to have better therapeutic effects. Everyone is Lor, so why can you make Le Dad? Therefore, most of them are just saving the country in a curve, finding a different type of target to get it out, so that you can go public.

Of course, different target types are always useful. There are thousands of humans, and it is hard to say which medicine is more suitable for you. There is no harm in choosing more.

The completely different types of antihypertensive drugs are even better for the majority of hypertensive patients.

Having said that, antihypertensive drugs ultimately need to lower blood pressure.

Can antihypertensive drugs that do not lower blood pressure and motivate other antihypertensive drugs?

Several scholars looked at each other, and Professor Jiang Xin, who was the leader, asked in a low voice: "So in terms of the current goal, have you achieved it?"

Yang Rui coughed twice and said in a real way: "From the second phase clinical point of view... no..."

"No...no? Well, okay...what are you going to do?" Professor Jiang Xin was about to hold back. If it were his student, he would have been beaten by shoehorns at this moment.

Yang Ruiwu smiled and said, "It is true that the preset goal has not been achieved, but everyone knows that the core of the clinical experiment is Phase 3. As long as the safety indicators are met, the efficacy is not forced to be achieved. We can expand the subject population in Phase 3 clinical trials to see if there can be any improvement..."

Yang Rui said seriously, and it was difficult for a few people to interrupt him, so he listened silently.

After finally waiting for Yang Rui to finish speaking, Wang Xiaoshu asked in Jiang Xin's ear: "Is what he said appropriate?"

"In theory, you can do the third phase of clinical practice." Jiang Xin gritted his teeth and said, "The rest is all nonsense."

Wang Xiaoshu suddenly felt that his blood pressure could not be controlled.

Unfortunately, there is nothing to control blood pressure on the spot.

"Why don't we go and hear what the doctor said?" Yang Rui led everyone inside, looking like he was leading a team to visit.

The subject cannot be directly contacted, so it doesn’t matter to the clinician.

The doctor on duty waved his hand and gave a report to a group of people.

No use.

This is how it is done for a double-blind experiment, which minimizes the placebo effect.

The so-called placebo effect is a case where the patient feels that he is about to recover and then he is actually cured.

Double-blind means that the patient and the doctor do not know whether they have received (issued) the real medicine or the placebo, which weakens the placebo effect.

Of course, for some drugs with obvious side effects, it is also difficult to conceal the effect of placebo.

For example, for common taste problems, clinical experimental centers often like to cover them with strawberry flavor. This shows that strawberry flavor is very suitable for covering up the odor, and it is not harmful to the little brothers and sisters who sell expired milk tea to read more.

"So, the most prominent point of sildenafil is the small side effects?" Jiang Xin couldn't help but summarize after listening to the clinician's report.

The clinician praised: "Yes, it's a very surprising performance. We haven't found any obvious side effects yet, and the response after the questionnaire survey was also very good."

Wang Xiaoshu, who had worked in a bank all his life, heard the problem of the conversation between the two and asked Jiang Xin in a low voice, saying, "Is it useless if the side effects are small?"

"The side effects of starch are also small, it will not cure the disease." Jiang Xin sighed in Wang Xiaoshu's ear. I don't know whether it was intentional or unintentional, but his voice became louder, which made everyone in front of him hear it.

The clinician blushed at first, glanced at Yang Rui, coughed, and said as if he didn't hear it: "The most important thing we pay attention to in the second phase of clinical practice is safety... At this point, sildenafil's performance is really good."

"There is no significant side effects, which does not mean good safety." Jiang Xin had no sense of awe of others, so he took the opportunity to say a word, and then peeked at Yang Rui.

Yang Rui had no idea.

Say there are no significant side effects of sildenafil? If this thing has side effects, can it be covered with a tent or not?

However, the clinical phase I and clinical phase II are not easy to show the side effects of sildenafil.

Equipping Viagra with aphrodisiac is a major misunderstanding among ordinary people.

Viagra is really a medicine. Its function is to resist ED, which means to help men who want to stand up but cannot stand up. Of course, it can also help men who are not standing straight and not standing up strong enough.

Spring @ medicine is different. It is because you have to stand even if you want to stand, and you have to stand even if you don’t want to stand. It is purely a punishment for standing.

To explain it with historical stories, when Li Shiming met Wu Meiniang in his later years, he needed Viagra to express his impulse. When Wu Meiniang in his later years summoned Zhang Yizhi and Zhang Changzong's brothers, the latter two wanted to express their impulse, and what he needed was aphrodisiac.

In Pfizer's clinical phase I, the subjects were all healthy people, and most of them were young and middle-aged. The men in it could be slightly tough on weekdays to show respect. There is actually no difference between whether to eat sildenafil or not.

This was originally a big selling point of sildenafil.

It helps you stand up when you want to stand up, and will not cause misunderstandings when you don’t want to stand up. Doesn’t this freedom represent the superiority of moneyism? If you have money, you can do whatever you want.

If it were rich, it would be Teddy, and the style would be too low.

But because of this, Pfizer's clinical phase 1 did not find any side effects of sildenafil at all.

In the second phase of clinical practice, it is actually similar.

The second phase of clinical practice is said to focus on safety and efficacy at the same time, but what it cares the most is actually safety. This is the so-called humanitarian new drug development model. The first phase of clinical practice usually has only 20 to 80 subjects. Its scope is too narrow and it is difficult to comprehensively examine the safety of drugs.

It can be said that the main purpose of the clinical phase I is to examine the universal toxicity to humans - the universal toxicity to animals has been screened through animal experiments.

Phase II of clinical practice is the real safety test.

A total of 100 to 300 patients, calculated in half, 50 to 150 people will take different doses of medicine.

Most of the side effects will be found in this test.

However, in order to pass the test as much as possible, pharmaceutical companies usually choose healthier subjects as possible.

If you ask the 75-year-old man who is plagued by illness to take the test, who will be the one who has something wrong?

Therefore, in the second phase of clinical practice, patients who take real sildenafil have problems with not standing upright. After all, it is a minority. It is not easy to meet a suitable person during the efficacy period.

In addition, it is a bit shy to become hard after all. Patients may not necessarily tell the truth if they encounter it.

It should be said that the birth of Viagra is still a certain degree of drama.

In the second phase of the experiment at the Clinical Experiment Center of Hedong University, Yang Rui intentionally increased the chance.

He asked the age group he selected to be more average, that is, he increased the average age, and he also asked the patient's condition to be more average, that is, he added (relatively) serious illnesses...

In this regard, several clinicians who performed the specific implementation were extremely impressed by Yang Rui.

In their opinion, this is the example of rigorous sect.

With hundreds of millions of dollars of compounds in hand, I still don’t forget to use the most scientific method to conduct clinical testing.

Jiang Xin is questioning clinicians on the surface, but actually questioning Yang Rui. In the eyes of several clinicians, it would be too much to question himself and the admirable Professor Yang.

Therefore, when Jiang Xin said something to criticize Sang and Huai, some doctors couldn't help but refute it.

Professor Yang’s efforts...

Professor Yang's rigor...

Professor Yang’s seeking truth from facts…

Wang Xiaoshu almost spit out an old mouthful of blood. Your sister is going to suffer from clinical trials. You are actually strict with over-standard?

Wang Xiaoshu felt that he had to stand out. This was the accusation given to him by the bank, and this was the last moment to protect the country's wealth and protect the people's property.

"Professor Yang!" Wang Xiaoshu shook his clothes and shouted with fearless spirit.

"Professor Yang..." A doctor pushed the door and said hurriedly: "The drug inventory is over."

The drug inventory was mentioned casually when Yang Rui came in, and it was considered a routine task.

Of course, Yang Rui himself was hiding deep meaning. He unconsciously smiled and asked, "Is it okay?"

"That..." the doctor stammered and did not answer.

"Let me tell you, everyone is here to listen to the report today."

"The finished product of sildenafil...is lost." The doctor lowered his head, very upset.

"How could this happen?" Yang Rui showed a "shocked" expression. In a flash, he first criticized himself: "I blame this for this. I shouldn't have set up a medicine cabinet in the ward. The designer reminded me at that time, and I said that our Chinese hospitals are used to this. Besides, who can't steal medicine..."

"Yes, how could anyone steal medicine!" Several clinicians deal with sildenafil every day, and they all felt it was incredible.

This is a drug in the experiment. It’s still uncertain whether it will be eaten to death. What should I do if I steal it home?
Chapter completed!