"Director Yang, what's going on here?" Pang Jiancheng asked Yang Rui with a smile, thinking to himself: His acting skills are quite good, Peking University is really hidden and hiding.

No one expected that new research results would emerge, and Pang Jiancheng naturally did not expect that it would be a supporting role for him just as Yang Rui arranged it.

On the contrary, several foreigners whispered as they listened to the "three-dimensional structure" mentioned by the translator.

Yang Rui hesitated for a moment, coughed twice, and said, "It seems that good news has been heard in our laboratory, so let's wait a moment."

After saying that, Yang Rui followed the student back to the laboratory and asked for the photos he took directly.

Gu Qiang and a group of people gathered in front of the electron microscope, with different expressions.

"I wanted to be idle and idle, so I took a few pictures. However, I made them with the remaining materials from the second phase of the repeated experiment. I wonder if it would interfere with the experimental results." Gu Qiang explained to Yang Rui with some pride and some concern.

The boss of the laboratory has all the power in the laboratory, and the people below have achieved results, which must be recognized by the boss.

Otherwise, if you encounter the worst laboratory leader, who refuses to admit the experimental results of his subordinates, or even denounces them as false, then your subordinates can only swallow their tears - going to another laboratory to do repeated experiments is a simpler and more difficult task. Otherwise, Yang Rui would not mobilize everyone that day and use a large amount of experiments and resources to do the second phase of repeated experiments. It is still in the same laboratory, and it will be even more difficult to change the laboratory.

Not only that, researchers who left the laboratory of big-name scholars will also encounter many other problems. Even if they prove their former views, they will not affect the big-name - if you have achieved results this time, it will neither prove that you did not make false this time nor the last time you did not make false this time.

The experiment where Galileo's two small balls fell at the same time was suspected of being faked. The correct theory does not mean that the experiment is correct.

On the contrary, more scholars who have lost their reputation and left the scientific research community sadly.

Therefore, no matter what achievements Gu Qiang made, his first and best choices will always be recognized by Yang Rui, and then it depends on how much credit Yang Rui can give him.

After the streptomycin incident, the value of the academic community to specific executors has become quite clear.

"Everything is spread a little bit and do your own business." Xu Zhengping drove everyone around him away before Yang Rui started watching the film.

Before the official publication of the paper, the photos of electron microscopes were first-hand evidence and first-hand information, and they must not be shown to others.

Biologists have always complained about Watson and Crick's Nobel Prize for sharing DNA double helix structure. One of the reasons is that they suspected that they had peeked at Rosalind Franklin's X-ray crystal diffraction pattern - of course, they must have looked at it. The key to the problem is whether it was peeking, because Ms. Franklin died early, and the arguments could no longer be refuted.

However, the key to the problem is actually a photo.

However, what kind of photo is the X-ray crystal diffraction pattern of DNA taken by Rosalind? The black background and white flowers, two crossed black reflective strips, were thrown on the street, and no one wanted to take a look at it.

Watson later wrote a book, saying that he was stunned and his heart was pounding, because only the spiral structure would appear in the photo as two crossed black reflective strips.

No matter what the photos Gu Qiang made were, they should not be public in the laboratory before the paper was published.

Just Xu Zhengping needed to remind him that all the researchers woke up and returned to their positions one by one. Only Gu Qiang looked at Yang Rui nervously.

Yang Rui nodded to Gu Qiang, then pulled out the photo and read it carefully.

Compared to others, Yang Rui has always had an advantage in reading images and other aspects.

He does not read the specific images of the photos, but only sees whether the images conform to the theory of three-dimensional structure. This is what all people who look at images need to do. Why do you need to learn chapters such as eight forms of fracture in school? It is to check whether there are corresponding elements on the image. If there is, it proves that it is a fracture. If there is no, it proves that there is no.

However, scholars in the 1980s knew very little about the three-dimensional structure of G protein-coupled receptors, which gave Yang Rui a relative advantage.

He only looked at it for a while, then put the image back into the bag, and then looked at Gu Qiang with his scrutiny.

"Director Yang..." Gu Qiang was a little guilty and shouted.

"Have you done the experimental record?"

"Do it." Gu Qiang quickly took it out. This is a good habit and a place where the ion channel laboratory is stronger than other laboratories. Even if it is a casual experiment, it must be recorded and recorded while doing it.

Experimental records are useless in most cases, but when you make discoveries, especially when you discover them in the world, your only regret is that the experimental records are not detailed enough!

"If I had..., I would have been better" is something that people who have not received systematic training often say.

The purpose of systematic training is to prepare researchers and seize every hard-won opportunity. After all, the number of times a person steps on shit in his life is limited, except Gu Qiang.

Yang Rui glanced at Gu Qiang again, and after reading the experimental records, he said, "There is no problem for the time being, but I still have to see the repeated experiment."

"Of course." Gu Qiang finished speaking and whispered: "If this is the case, will the three-dimensional structure be created?"

Yang Rui hesitated for a moment and said, "Basically."

"Yeah!" Gu Qiang shouted softly.

"We also need to improve the remaining parts and draw the three-dimensional structure, but this is basically the case. The rest are rough work." Yang Rui also sighed a little.

Regarding the third phase of experiment, that is, the three-dimensional structure of G protein-coupled receptors, the most important and most important requirement is to find the activation mode of small extracellular ligands and G protein-coupled receptors.

Simply put, G protein-coupled receptor is a protein that is invisible to the naked eye, but it is very large at the molecular level. It is like a molecular building, with people and cars constantly coming in and out.

These people or cars entering and leaving are extracellular ligands.

For example, how does a person's sense of smell come about?

The air in the outside world contains various molecules. They enter the human nose. Some of the molecules that can be distinguished by humans will come into contact with a certain G-protein-coupled receptor in the human body. This molecule is a pedestrian entering the G-protein-coupled receptor building.

Pedestrians enter the building, and the building sends a signal to the brain. The brain searches for information and tells humans what you just smelled.

To define the three-dimensional structure of the G-protein-coupled receptor, we need to describe the appearance of the building. The most difficult thing is not the outline - the huge G-protein-coupled receptor is still easy to make. The most difficult, most important part is to see how it accepts pedestrians and vehicles.

Specifically, it depends on the positions and shapes of various openings on G-protein-coupled receptor molecules.

In other words, what humans want to know is where the elevator of this G-protein coupled receptor building is, where the garage door is, where the front side door and the back door are, and whether there is a bridge and rooftop.

Using instruments to scan G-protein coupled receptors is like scanning a building with a laser. They do not really see everything about the building, but rely on various feedback to get answers.

It's like shining a laser on the door of a building. If the door is closed, the laser will give a reflection and get the wrong answer that there is no door here.

Scanning G-protein-coupled receptors is more complicated because proteins can move. Only when they are related to extracellular ligands will it show the necessary three-dimensional structure. Otherwise, it will be a closed protein.

Speaking of which, G protein-coupled receptors often exchange with the outside world, but it is very challenging to seize such a moment of picture.

Historically, it took Kobe Carl about 4 years to explode his character and photographed the scene he needed - the moment when a certain extracellular ligand, the G-protein-coupled receptor touched.

Gu Qianggui spent four months doing related research.

Dog @大天女台有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有有

But for Yang Rui, this time was too coincidental.

"You continue to do repeated experiments and write down all the experimental records you can remember." Yang Rui could not give up this result. The next time he took the photo he wanted, he knew what century it was.

However, Yang Rui could not let these achievements be exposed to the Swedes without any preparation.

The temptation of the Nobel Prize is something that no scholar can resist.

"Who can take over the repetitive experiment?" Yang Rui asked loudly.

Several researchers looked at each other, and finally Su Xiankai stood up.

Yang Rui nodded and said, "Now, distinguish the second phase of experiment from the third phase of experiment. The electron microscope is not allowed to move. Tian Bing, you will help Gu Qiang make records."

It is normal to improve the records first and then repeat the laboratory.

After a little busy life in the laboratory, Yang Rui looked at the electron microscope again, and although hesitated, he still walked out.

"Everyone, we have just completed a new round of repeated experiments, proving that we have obtained the crystal structure diagram of the complex that binds the N-terminal ligand domain of the G-protein-coupled receptor and the ligand. " Yang Rui faced a group of Swedes with a hot pot to stick out his tongue in a hot pot.

...
Chapter completed!